Pertussis literature review

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Can Commun Dis Rep. Background: In Canada, pertussis is an endemic and cyclical disease, with peaks occurring at two- to five-year intervals. Although pertussis incidence varies by age group, unvaccinated or undervaccinated infants are at greatest risk of infection and associated complications. Since the last National Advisory Committee on Immunization NACI recommendations published in , new evidence on the safety and effectiveness of tetanus toxoid, reduced diphtheria toxoid and reduced acellular pertussis Tdap vaccine administration in pregnancy has become available. Objective: To provide guidance on maternal immunization in pregnancy as a strategy to reduce disease incidence and severe outcomes defined as hospitalization or death from pertussis infection in infants less than 12 months of age. Methods: The NACI reviewed evidence on the burden of disease in Canada, vaccine safety and immunogenicity and vaccine effectiveness in jurisdictions that have implemented maternal immunization programs.

Pertussis Vaccine Analysis

Pertussis vaccine: Canadian Immunization Guide - henrigougaud.info

This review summarizes the published data on epidemiology and burden of pertussis in South Korea as these may be under-categorized. Pertussis detection rates among 19 eligible studies range from 0. Highest rates are observed in infants, while adolescents and adults with pertussis infection may suffer from persistent coughing. Vaccination uptake of pertussis booster dose among adolescents and adults remains low while seropositivity detection of anti-pertussis immunoglobulin G , is high among adults. This review reveals a high burden of vaccine-preventable pertussis in South Korea. Besides primary childhood vaccination, strategies like maternal immunization and decennial revaccination of adults should be considered.

Postexposure Antimicrobial Prophylaxis

Organization: Public Health Agency of Canada. Published: February Cat. PHAC acknowledges that the advice and recommendations set out in this statement are based upon the best current available scientific knowledge and is disseminating this document for information purposes. People administering the vaccine should also be aware of the contents of the relevant product monograph s.
Objective: This study is conducted to summarise and present the current knowledge on antenatal vaccination against pertussis with regard to national recommendations, coverage, immunogenicity, safety and effectiveness of the current available vaccines. Methods: A systematic review of the literature in English was undertaken from January to May with searches in four databases. Results: 47 studies fulfilled the inclusion criteria.
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