Cytisine for smoking cessation a literature review and a meta analysis

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Bupropion , sold under the brand names Wellbutrin and Zyban among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. Common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. Bupropion acts as a norepinephrine—dopamine reuptake inhibitor and a nicotinic receptor antagonist. Bupropion was invented by Nariman Mehta in , who worked at Burroughs Wellcome.
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Bupropion - Wikipedia

Varenicline trade name Chantix and Champix is a prescription medication used to treat nicotine addiction. It both reduces craving for and decreases the pleasurable effects of cigarettes and other tobacco products. It is estimated that varenicline successfully helps one of every 11 people who smoke remain abstinent from tobacco at six months. Varenicline is used to help people stop smoking tobacco smoking cessation. A Cochrane overview and network meta-analysis concluded that varenicline is the most effective medication for tobacco cessation and that smokers were nearly three times more likely to quit on varenicline than with placebo treatment. Varenicline was more efficacious than bupropion or NRT and as effective as combination NRT for tobacco smoking cessation.
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Quitting Smoking With Complementary Health Approaches: What You Need To Know

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