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Induktion von zytotoxischen T-Zellen gegen das Minorhistokompatibilitätsantigen HA-1
Hela Zellen Dissertations
CD25 hingegen kommt auf YacZellen vor. The membrane anchored ART2 is an extracellular enzyme, which uses NAD as a substrate to covalently ADP-ribosylate membrane proteins on arginine residues in a posttranslational reaction, producing nicotinamide as a byproduct of the reaction. Two known targets of this reaction are CD25, the alpha subunit of the trimeric IL-2 receptor complex and the homophilic interaction molecule CD CD25 is of importance for the clonal expansion of activated lymphocytes. As a member of the immunoglobulin superfamily CD is expressed mainly on B- and T-lymphocytes and is thought to participate in forming the immunological synapse, the contact area between B-cell and T-cell. CD is recruited to the area of contact and interacts homophilically. In the first part of the dissertation, different lymphoma cell lines were examined for their expression of known ART2-target proteins.
Regulatorische t-zellen dissertation
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